Haley Donow, B.S.
Lab Manager I
Office: CTS 209
Haley Donow is the lab manager and senior research chemist for Dr. Marcello Giulianotti’s synthetic chemistry group at the Florida International University’s Center for Translational Science. Haley completed her Bachelor of Science degree in Chemistry at the University of Florida in 2018. Since 2019, she has been a part of Dr. Giulianotti’s lab in varying capacities, initially as a research technician at the Torrey Pines Institute for Molecular Studies, then as a senior research chemist, and now as lab manager with Dr. Giulianotti’s group joining FIU. She is highly experienced with the solid-phase synthesis and purification of peptides and small molecules.
Peptide libraries, small molecule libraries, library screening, library positional scanning, library deconvolution, hit to lead optimization, medicinal chemistry
Ramadan, A.A.; Mayilsamy, K.; McGill, A.R.; Ghosh, A.; Giulianotti, M.A.; Donow, H.M.; Mohapatra, S.S.; Mohapatra, S.; Chandran, B.; Deschenes, R.J.; Roy, A. Identification of SARS-CoV-2 Spike Palmitoylation Inhibitors That Results in Release of Attenuated Virus with Reduced Infectivity. Viruses 2022, 14, 531. https://doi.org/10.3390/v14030531
Ericson, M.D.; Doering, S.R.; Larson, C.M.; Freeman, K.T.; LaVoi, T.M.; Donow, H.M.; Santos, R.G.; Cho, R.H.; Koerperich, Z.M.; Giulianotti, M.A.; Pinilla, C. Functional mixture-based positional scan identifies a library of antagonist tetrapeptide sequences (LAtTeS) with nanomolar potency for the melanocortin-4 receptor and equipotent with the endogenous AGRP (86-132) antagonist. Journal of medicinal chemistry 2021, 64(19), 14860-14875. https://doi.org/10.1021/acs.jmedchem.1c01417
Rocha, K.; Magallon, J.; Reeves, C.; Phan, K.; Vu, P.; Oakley-Havens, C.L.; Kwan, S.; Ramirez, M.S.;LaVoi, T.; Donow, H.; Chapagain, P. Inhibition of Aminoglycoside 6′-N-acetyltransferase Type Ib (AAC (6′)-Ib): Structure–Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors. Biomedicines 2021, 9(9), 1218. https://doi.org/10.3390/biomedicines9091218
Donow, H. M.; Short, G. N.; Miller, S. A. Synthesis and polymerization of bio-cyclic monomers in pursuit of viable alternatives to commodity plastics. Presented at the 2018 Florida Annual Meeting and Exposition Conference of the American Chemical Society, Palm Harbor, FL, May 3, 2018. University of Florida.