Clemencia Pinilla, PhD
Principal Scientist, Office of Research and Economic Development
FIU Center for Translational Science
Email: cpinilla@fiu.edu
FIU Discovery
Overview
Dr. Clemencia Pinilla is recognized as a pioneer in the field of combinatorial chemistry and the inventor of positional scanning libraries. She has over 30 years of research experience in the identification of ligands using mixture-based libraries, supported by more than 145 peer-review publications. She joined Florida International University (FIU) in March 2020 as part of the group of investigators from Torrey Pines Institute for Molecular Studies. Dr. Pinilla has work closely with other investigators now at the Center of Translational Sciences at FIU on all the aspects of ligand identification for basic research and drug-lead discovery.
Most of Dr. Pinilla’s current work focuses on T-cell specificity, identification of melanocortin receptor ligands and identification of compounds that inhibit antimicrobial resistance.
Recent Publications:
1. Greaves, S. A., A. Ravindran, R. G. Santos, L. Chen, M. T. Falta, Y. Wang, A. M. Mitchell, S. M. Atif, D. G. Mack, A. N. Tinega, L. A. Maier, S. Dai, C. Pinilla, J. Grunewald and A. P. Fontenot. 2021. CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope. J Exp Med. 218:10. 2021: The Year in Experimental Medicine
2. Doering SR, Freeman K, Debevec G, Geer P, Santos RG, Lavoi TM, Giulianotti MA, Pinilla C, Appel JR, Houghten RA, Ericson MD, Haskell-Luevano C. Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput “Unbiased” Screening Campaign. J Med Chem. 2021 May 13;64(9):5577-5592.
3. Rocha, K.; Magallon, J.; Reeves, C.; Phan, K.; Vu, P.; Oakley-Havens, C.L.; Kwan, S.; Ramirez, M.S.; LaVoi, T.; Donow, H.; Chapagain, P.; Santos, R.; Pinilla, C.; Giulianotti, M.A.; Tolmasky, M.E. 2021. Inhibition of Aminoglycoside 6′-N-acetyltransferase Type Ib (AAC(6′)-Ib): Structure–Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors. Biomedicines 9:1218.
Research Interests
Ligand identification using combinatorial libraries, T cell specificity, G-coupled protein receptors, Infectious diseases
Recent Publications
Research Interests
- Pulmonary Vascular Disease
- Dry Powder Inhalers; Spray Drying; Inhalation
- Monocrotaline; Type II Bone Morphogenetic Protein Receptor; Pulmonary Hypertension
- Renalase; NAD(P)H Oxidase (H2o2-forming); Apocynin
- Myosin Light Chain Kinase; Cadherin 5; ML 7
- Persistent Fetal Circulation Syndrome; Ductus Arteriosus; Pulmonary Hypertension
Abstracts
Education
Professional Honors
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