Dr. Xia’s most recent publications.

  1. Detergent-insoluble inclusion constitutes the first pathology in PFN1 transgenic rats. Yuan G, Cui S, Chen X, Song H, Huang C, Tong J, Yuan Z, Yu L, Xiong X, Zhao J, Huang B, Wu Q, Zhou Y, Chen G, Zhou H, Xia XG. Journal of Neurochemistry 2021 May;157(4):1244-1252. doi: 10.1111/jnc.15139. Epub 2020 Aug 12.PMID: 32754913
  2. Increased Ubqln2 expression causes neuron death in transgenic rats. Huang B, Wu Q, Zhou H, Huang C, Xia XG. Journal of Neurochemistry 2016 Oct;139(2):285-293. doi: 10.1111/jnc.13748.PMID: 27456931
  3. Pathogenic Ubqln2 gains toxic properties to induce neuron death. Wu Q, Liu M, Huang C, Liu X, Huang B, Li N, Zhou H, Xia XG. Acta Neuropathologica 2015 Mar;129(3):417-28. doi: 10.1007/s00401-014-1367-y. Epub 2014 Nov 12.PMID: 25388785
  4. Profiling the genes affected by pathogenic TDP-43 in astrocytes. Huang C, Huang B, Bi F, Yan LH, Tong J, Huang J, Xia XG, Zhou H. Journal of Neurochemistry 2014 Jun;129(6):932-9. doi: 10.1111/jnc.12660. Epub 2014 Feb 9.PMID: 24447103
  5. Cytosolic PINK1 escapes from mitochondria to promote dendritic outgrowth. Tieu K, Xia XG. Journal of Neurochemistry 2014 Mar;128(6):787-9. doi: 10.1111/jnc.12529. Epub 2013 Nov 22.PMID: 24261349
  6. Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats. Tong J, Huang C, Bi F, Wu Q, Huang B, Liu X, Li F, Zhou H, Xia XG. The EMBO Journal 2013 Jul 3;32(13):1917-26. doi: 10.1038/emboj.2013.122. Epub 2013 May 28.PMID: 23714777
  7. Reactive astrocytes secrete lcn2 to promote neuron death. Bi F, Huang C, Tong J, Qiu G, Huang B, Wu Q, Li F, Xu Z, Bowser R, Xia XG, Zhou H. Proceedings of the National Academy of Sciences U.S.A. 2013 Mar 5;110(10):4069-74. doi: 10.1073/pnas.1218497110. Epub 2013 Feb 19.PMID: 23431168
  8. Entorhinal cortical neurons are the primary targets of FUS mislocalization and ubiquitin aggregation in FUS transgenic rats. Huang C, Tong J, Bi F, Wu Q, Huang B, Zhou H, Xia XG. Human Molecular Genetics 2012 Nov 1;21(21):4602-14. doi: 10.1093/hmg/dds299. Epub 2012 Jul 23.PMID: 22833456
  9. Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats. Huang C, Tong J, Bi F, Zhou H, Xia XG. The Journal of Clinical Investigation 2012 Jan;122(1):107-18. doi: 10.1172/JCI59130. Epub 2011 Dec 12.PMID: 22156203
  10. TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic mice. Tian T, Huang C, Tong J, Yang M, Zhou H, Xia XG. International Journal of Biological Sciences 2011 Mar 4;7(2):234-43. doi: 10.7150/ijbs.7.234.PMID: 21448284
  11. Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake. Zhou H, Huang C, Tong J, Hong WC, Liu YJ, Xia XG. International Journal of Biological Sciences 2011;7(6):753-61. doi: 10.7150/ijbs.7.753. Epub 2011 Jun 9.PMID: 21698001
  12. Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice. Zhou H, Huang C, Tong J, Xia XG. International Journal of Biological Sciences 2011;7(8):1180-7. doi: 10.7150/ijbs.7.1180. Epub 2011 Oct 26.PMID: 22043175
  13. FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Huang C, Zhou H, Tong J, Chen H, Liu YJ, Wang D, Wei X, Xia XG. PLOS Genetics 2011 Mar;7(3):e1002011. doi: 10.1371/journal.pgen.1002011. Epub 2011 Mar 3.PMID: 21408206
  14. Transgenic rat model of neurodegeneration caused by mutation in the TDP gene. Zhou H, Huang C, Chen H, Wang D, Landel CP, Xia PY, Bowser R, Liu YJ, Xia XG. PLOS Genetics 2010 Mar 26;6(3):e1000887. doi: 10.1371/journal.pgen.1000887.PMID: 20361056
  15. Developing tTA transgenic rats for inducible and reversible gene expression. Zhou H, Huang C, Yang M, Landel CP, Xia PY, Liu YJ, Xia XG. International Journal of Biological Sciences 2009;5(2):171-81. doi: 10.7150/ijbs.5.171. Epub 2009 Jan 29.PMID: 19214245
  16. A tightly regulated Pol III promoter for synthesis of miRNA genes in tandem. Zhou H, Huang C, Xia XG. Biochimica et Biophysica Acta 2008 Nov;1779(11):773-9. doi: 10.1016/j.bbagrm.2008.03.011. Epub 2008 Apr 7.PMID: 18439919
  17. Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice. Zhou H, Falkenburger BH, Schulz JB, Tieu K, Xu Z, Xia XG. International Journal of Biological Sciences 2007 Mar 5;3(4):242-50. doi: 10.7150/ijbs.3.242.PMID: 17389931
  18. Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. Xia XG, Zhou H, Samper E, Melov S, Xu Z. PLOS Genetics 2006 Jan;2(1):e10. doi: 10.1371/journal.pgen.0020010. Epub 2006 Jan 27.PMID: 16450009
  19. An RNAi strategy for treatment of amyotrophic lateral sclerosis caused by mutant Cu,Zn superoxide dismutase. Xia XG, Zhou H, Zhou S, Yu Y, Wu R, Xu Z. Journal of Neurochemistry 2005 Jan;92(2):362-7. doi: 10.1111/j.1471-4159.2004.02860.x.PMID: 15663483
  20. Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson’s disease. Xia XG, Harding T, Weller M, Bieneman A, Uney JB, Schulz JB. Proceedings of the National Academy of Sciences U.S.A. 2001 Aug 28;98(18):10433-8. doi: 10.1073/pnas.181182298. Epub 2001 Aug 14. PMID: 11504916