Dr. Nefzi’s most recent publications.

  1. Discovery of a Lead Compound for Specific Inhibition of Type I Collagen Production in Fibrosis. Stefanovic B, Michaels HA, Nefzi A. ACS Medicinal Chemistry Letters       2021 Feb 24;12(3):477-484. doi: 10.1021/acsmedchemlett.1c00006. eCollection 2021 Mar 11.PMID: 33738075
  2. Small Molecule Compounds Identified from Mixture-Based Library Inhibit Binding between Plasmodium falciparum Infected Erythrocytes and Endothelial Receptor ICAM-1. Chesnokov O, Visitdesotrakul P, Kalani K, Nefzi A, Oleinikov AV. International Journal of Molecular Sciences 2021 May 26;22(11):5659. doi: 10.3390/ijms22115659.PMID: 34073419
  3. Evaluating the effect of dermaseptin S4 and its derivatives on multidrug-resistant bacterial strains and on the colon cancer cell line SW620. Belaid A, Braiek A, Alibi S, Hassen W, Beltifa A, Nefzi A, Mansour HB. Environmental Science and Pollution Research (International) 2021 Mar 27. doi: 10.1007/s11356-021-13683-2. Online ahead of print.PMID: 33774792
  4. Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinase. Ortiz MA, Michaels H, Molina B, Toenjes S, Davis J, Marconi GD, Hecht D, Gustafson JL, Piedrafita FJ, Nefzi A. Bioorganic & Medicinal Chemistry Letters 2020 May 1;30(9):127108. doi: 10.1016/j.bmcl.2020.127108. Epub 2020 Mar 17.PMID: 32192797
  5. Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs. Harris HM, Eans SO, Ganno ML, Davis JC, Dooley CT, McLaughlin JP, Nefzi A. Organic & Biomolecular Chemistry 2019 Jun 7;17(21):5305-5315. doi: 10.1039/c9ob00882a. Epub 2019 May 16.PMID: 31094391
  6. Identification of Bis-Cyclic Guanidines as Antiplasmodial Compounds from Positional Scanning Mixture-Based Libraries. Perry DL Jr, Roberts BF, Debevec G, Michaels HA, Chakrabarti D, Nefzi A. Molecules 2019 Mar 20;24(6):1100. doi: 10.3390/molecules24061100.PMID: 30897744
  7. Scaffold Ranking and Positional Scanning Identify Novel Neurite Outgrowth Promoters with Nanomolar Potency. Al-Ali H, Debevec G, Santos RG, Houghten RA, Davis JC, Nefzi A, Lemmon VP, Bixby JL, Giulianotti MA. ACS Medicinal Chemistry Letters 2018 Sep 24;9(10):1057-1062. doi: 10.1021/acsmedchemlett.8b00425. eCollection 2018 Oct 11.PMID: 30344917
  8. Synthesis of dihydroimidazole tethered imidazolinethiones and their activity as novel antagonists of the nuclear retinoic acid receptor-related orphan receptors (RORs). Nefzi A, Marconi GD, Ortiz MA, Davis JC, Piedrafita FJ. Bioorganic & Medicinal Chemistry Letters 2017 Apr 1;27(7):1608-1610. doi: 10.1016/j.bmcl.2017.02.014. Epub 2017 Feb 10.PMID: 28242276
  9. ANTISTAPHYBASE: database of antimicrobial peptides (AMPs) and essential oils (EOs) against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus. Zouhir A, Taieb M, Lamine MA, Cherif A, Jridi T, Mahjoubi B, Mbarek S, Fliss I, Nefzi A, Sebei K, Ben Hamida J. Archives of Microbiology 2017 Mar;199(2):215-222. doi: 10.1007/s00203-016-1293-6. Epub 2016 Sep 26.PMID: 27671474
  10. Inhibition of methicillin-resistant Staphylococcus aureus (MRSA) by antimicrobial peptides (AMPs) and plant essential oils. Zouhir A, Jridi T, Nefzi A, Ben Hamida J, Sebei K. Pharmaceutical Biology 2016 Dec;54(12):3136-3150. doi: 10.1080/13880209.2016.1190763. Epub 2016 Jun 1.PMID: 27246787
  11. Synthesis and antitubercular activity of 1,2,4-trisubstitued piperazines. Rohde KH, Michaels HA, Nefzi A. Bioorganic & Medicinal Chemistry Letters 2016 May 1;26(9):2206-9. doi: 10.1016/j.bmcl.2016.03.063. Epub 2016 Mar 16.PMID: 27020522
  12. Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines. Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L. ACS Combinatorial Science 2016 Jan 11;18(1):51-64. doi: 10.1021/acscombsci.5b00126. Epub 2016 Jan 5.PMID: 26651386
  13. Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT). Dong H, Madegowda M, Nefzi A, Houghten RA, Giulianotti MA, Rosen BP. Chemical Research in Toxicology 2015 Dec 21;28(12):2419-25. doi: 10.1021/acs.chemrestox.5b00432. Epub 2015 Dec 6.PMID: 26577531
  14. Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors. Eans SO, Ganno ML, Mizrachi E, Houghten RA, Dooley CT, McLaughlin JP, Nefzi A Journal of Medicinal Chemistry 2015 Jun 25;58(12):4905-17. doi: 10.1021/jm501637c. Epub 2015 Jun 4.PMID: 25996309
  15. Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens. Fleeman R, LaVoi TM, Santos RG, Morales A, Nefzi A, Welmaker GS, Medina-Franco JL, Giulianotti MA, Houghten RA, Shaw LN. Journal of Medicinal Chemistry 2015 Apr 23;58(8):3340-55. doi: 10.1021/jm501628s. Epub 2015 Apr 1.PMID: 25780985
  16. Diversity oriented synthesis and IKK inhibition of aminobenzimidazole tethered quinazoline-2,4-diones, thioxoquinazolin-4-ones, benzodiazepine-2,3,5-triones, isoxazoles and isoxazolines. Dadiboyena S, Arfaoui A, Amri H, Piedrafita FJ, Nefzi A. Bioorganic & Medicinal Chemistry Letters 2015 Feb 1;25(3):685-9. doi: 10.1016/j.bmcl.2014.11.078. Epub 2014 Dec 8.PMID: 25522820
  17. Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin. Hammami S, Mighri Z, Dooley CT, Nefzi A. Bioorganic & Medicinal Chemistry Letters 2014 Sep 15;24(18):4482-4485. doi: 10.1016/j.bmcl.2014.07.090. Epub 2014 Aug 8.PMID: 25168746
  18. Substituted dithiazole piperazine benzamides as novel amyloid beta peptide reducing agents. Wang H, Wang R, Lakshmana MK, Nefzi A. Bioorganic & Medicinal Chemistry Letters 2014 Sep 15;24(18):4384-4388. doi: 10.1016/j.bmcl.2014.08.022. Epub 2014 Aug 13.PMID: 25155386
  19. AlphaLISA-based high-throughput screening assay to measure levels of soluble amyloid precursor protein α. Wang H, Nefzi A, Fields GB, Lakshmana MK, Minond D. Analytical Biochemistry 2014 Aug 15;459:24-30. doi: 10.1016/j.ab.2014.05.007. Epub 2014 May 20.PMID: 24857774
  20. Synthesis of trifunctional thiazolyl amino acids and their use for the solid-phase synthesis of small molecule compounds and cyclic peptidomimetics. Michaels HA, Velosa DC, Nefzi A. ACS Combinatorial Science 2014 Jan 13;16(1):1-4. doi: 10.1021/co400114u. Epub 2013 Dec 27.PMID: 24369098